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The role of autoantibodies in the pathogenesis of immune-mediated cytopenias has been of great clinical interest since the demonstration of anti-erythrocyte antibodies, in certain types of anemia, by Coombs and co-workers in 1945. Since then, such antibodies have also been found in thrombocytopenia and neutropenia. Antibody detection assays have been developed to study these autoantibodies, but the assays are usually confined to specialty laboratories and are not available in a standard form suitable for use in routine clinical laboratories.
Many different techniques are described in the medical literature, but until now there has never been a laboratory manual available that
Immune Cytopenias.. Ann Intern Med. ;100:629–630. doi: 10.7326/0003-4819-100-4-629_4
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Published: Ann Intern Med. 1984;100(4):629-630.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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