JEROME E. GROOPMAN, M.D.; MICHAEL S. GOTTLIEB, M.D.; JESSE GOODMAN, M.D.; RONALD T. MITSUYASU, M.D.; MARCUS A. CONANT, M.D.; HARRY PRINCE, Ph.D.; JOHN L. FAHEY, M.D.; MARVIN DEREZIN, M.D.; WILFRED M. WEINSTEIN, M.D.; CONRAD CASAVANTE, Ph.D.; JOHN ROTHMAN, Ph.D.; SETH A RUDNICK, M.D.; PAUL A. VOLBERDING, M.D.
In a randomized prospective study we tested the toxicity and efficacy of recombinant alpha-2 interferon in the treatment of Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. High doses (50 X 106 U/m2 body surface area, intravenously) or low doses (1 X 106 U/m2, subcutaneously) of recombinant alpha-2 interferon were administered to 20 patients for 5 days/ wk, every other week, for four treatment cycles. Therapy was well tolerated subjectively and caused only mild hematologic and hepatic toxicity at both dose levels. No consistent or sustained changes were seen in immunologic variables during or after treatment. Six patients with Kaposi's sarcoma, four at high dose and two at low dose, had objective responses (complete or partial) to treatment. However, therapy did not appear to eradicate cytomegalovirus carriage or prevent opportunistic infections related to cytomegalovirus.
GROOPMAN JE, GOTTLIEB MS, GOODMAN J, MITSUYASU RT, CONANT MA, PRINCE H, et al. Recombinant Alpha-2 Interferon Therapy for Kaposi's Sarcoma Associated with the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;100:671–676. doi: 10.7326/0003-4819-100-5-671
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Published: Ann Intern Med. 1984;100(5):671-676.
Hematology/Oncology, Infectious Disease.
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