C. RICHARD BOLAND, M.D.; FRANK J. TRONCALE, M.D.
Colorectal carcinoma is primarily caused by environmental factors (1), but a small subset of patients is unusually susceptible to colonic cancer on a familial basis and virtually all family members who inherit the critical gene can be expected to develop cancer eventually. The best known of these syndromes are familial polyposis coli and Gardner's syndrome, both easily recognizable because multiple adenomatous polyps precede the appearance of carcinoma in the colon. Less commonly recognized are the familial colonic cancer syndromes without antecedent polyposis. Such cases are important to recognize because of the serious implications for relatives of those affected.
BOLAND CR, TRONCALE FJ. Familial Colonic Cancer Without Antecedent Polyposis. Ann Intern Med. ;100:700–701. doi: 10.7326/0003-4819-100-5-700
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Published: Ann Intern Med. 1984;100(5):700-701.
Colorectal Cancer, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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