PETER A. CASSILETH, M.D.; EDWARD J. LUSK, Ph.D.; SUSAN TORRI, R.N.; STANTON L. GERSON, M.D.
Nausea and vomiting continue to be distressing side effects of cancer chemotherapy. We recently reported (1) a randomized, double-blind study in which a single 10-mg dose of intravenous dexamethasone markedly reduced the gastrointestinal side effects of mildly emetogenic chemotherapy for outpatients with breast cancer. We now report the safety and efficacy of repeated doses of dexamethasone in eliminating the nausea and vomiting of induction chemotherapy for patients with acute nonlymphocytic leukemia.
All patients included in the study were adults with acute nonlymphocytic leukemia (at diagnosis or on relapse) at the Hospital of the University of Pennsylvania and were treated with
CASSILETH PA, LUSK EJ, TORRI S, GERSON SL. Antiemetic Efficacy of High-Dose Dexamethasone in Induction Therapy in Acute Nonlymphocytic Leukemia. Ann Intern Med. ;100:701–702. doi: 10.7326/0003-4819-100-5-701
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Published: Ann Intern Med. 1984;100(5):701-702.
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