DAVID S. SHIMM, M.D.; LEO E. GERWECK, PH.D.
Hyperthermia for the treatment of cancer was first used by Coley (1) in this country in 1893. After a period of eclipse, hyperthermia has enjoyed a recent surge in interest on the part of engineers, biologists, and clinicians. Research into the biology of hyperthermia has concentrated on the physiologic conditions that alter response to hyperthermia, and the phenomenon of thermo-tolerance, whereby cells surviving an initial heat treatment sustain transient resistance to subsequent heat treatments. The response to hyperthermia is increased in the presence of combined acute hypoxia and glucose deprivation (2), chronic hypoxia alone (3), or low pH (4). Cells
SHIMM DS, GERWECK LE. Hyperthermia in the Treatment of Cancer. Ann Intern Med. ;100:757–759. doi: 10.7326/0003-4819-100-5-757
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Published: Ann Intern Med. 1984;100(5):757-759.
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