JAMES L. WADE III, M.D.; JAMES R. TAYLOR, M.D.; JOHN E. ULTMANN, M.D.
To the editor: The recent report of B-cell lymphomas in homosexual men (1) documents an important aspect of the acquired immunodeficiency syndrome. All six patients described had B-cell lymphomas, and five had a monoclonal light chain surface immunoglobulin. This finding supports the premise that in the background of immunosuppression, a stimulus to B cells can trigger neoplastic growth of a single clone. This phenomenon has been described recently by Cleary and colleagues (2) in patients who had cardiac transplantation; these ten patients with lymphoma also had a monoclonal proliferation of malignant B cells. However, lymphomas that arise in immunosuppressed patients
WADE JL, TAYLOR JR, ULTMANN JE. Diffuse Immunoblastic Sarcoma from Benign Lymphoid Proliferation. Ann Intern Med. 1984;100:765. doi: 10.7326/0003-4819-100-5-765_2
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Published: Ann Intern Med. 1984;100(5):765.
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