KURT ELWARD, M.D.; FREDERICK BARKEN, M.D.; JEFFREY A. LOVOLD, M.D.
To the editor: The article by Goldstein and colleagues (1) implicates advanced age as a predisposing factor for the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Recently we treated an 86-year-old white man who had had hyponatremia diagnosed in 1980. He has had mild congestive heart failure treated with digoxin and metolazone. His serum sodium level 7 days after discontinuation of metolazone and restriction of fluids was 125 meq/L. Neurologic findings were normal, except for mildly diminished short-term memory. Chest roentgenograms, thyroid function tests, and morning cortisol levels were all normal. Serum osmolality was 261 mmol/L. Spot urine osmolality was
ELWARD K, BARKEN F, LOVOLD JA. Age and Inappropriate Antidiuretic Hormone Secretion. Ann Intern Med. ;100:766. doi: 10.7326/0003-4819-100-5-766_1
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Published: Ann Intern Med. 1984;100(5):766.
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