D. ROGER ILLINGWORTH, M.D., Ph.D.; WILLIAM E. CONNOR, M.D.
Familial hypercholesterolemia is an autosomal dominant disorder associated with lifelong hypercholesterolemia and premature atherosclerosis (1). Treatment of patients heterozygous for this disorder has included diet, medications (colestipol, nicotinic acid, probucol) (2), and in certain patients surgical bypass of the distal ileum (3). By selectively removing the site of bile acid reabsorption, distal ileal bypass surgery results in enhanced fecal excretion of bile acids; an increased rate of hepatic conversion of cholesterol to bile acids; and, by depleting the hepatic pool of cholesterol, an increase in the number of high-affinity receptors for low-density lipoproteins (LDL) on hepatocyte membranes with a concomittant
ILLINGWORTH DR, CONNOR WE. Hypercholesterolemia Persisting After Distal Ileal Bypass: Response to Mevinolin. Ann Intern Med. ;100:850–851. doi: 10.7326/0003-4819-100-6-850
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Published: Ann Intern Med. 1984;100(6):850-851.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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