M. COLIN JORDAN, M.D.; GEORGE W. JORDAN, M.D.; JACK G. STEVENS, D.V.M., Ph.D.; GEORGE MILLER, M.D.
The herpesviruses that infect humans characteristically establish a latent infection that may be reactivated later. The consequences of reactivation range from asymptomatic shedding to severe disseminated infection. Varicella-zoster and herpes simplex viruses are both highly neurotropic, establishing nonreplicating infections in sensory ganglia. Latent herpes simplex virus is known to reside in neurons, and the virus-cell interactions involved have been defined to an extent. Cytomegalovirus and Epstein-Barr virus interact with peripheral blood leukocytes. Latent cytomegalovirus infection of human leukocytes has not been proved, although studies in a murine model have implicated B lymphocytes as a repository of latent virus. Epstein-Barr virus is known to persist in a non-replicating state as extrachromosomal DNA in B lymphocytes and to cause "immortalization" of the infected cell; persistence of the viral genome in epithelial cells may also result in malignant transformation, such as nasopharyngeal carcinoma.
JORDAN MC, JORDAN GW, STEVENS JG, MILLER G. Latent Herpesviruses of Humans. Ann Intern Med. ;100:866–880. doi: 10.7326/0003-4819-100-6-866
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Published: Ann Intern Med. 1984;100(6):866-880.
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