OSCAR D. RATNOFF, M.D.; MICHAEL M. LEDERMAN, M.D.; JAY JENKINS, M.D.
To the editor: Palpable axillary or epitrochlear lymph nodes or splenic enlargement has been reported in patients with classic hemophilia treated with lyophilized concentrates of antihemophilic factor (factor VIII) (1-3). These abnormalities have been found in at least 14 of 92 hemophiliacs enrolled in home therapy programs in northeast Ohio during the last 3 years.
In September 1983, a 23-year-old male hemophiliac was examined at University Hospitals of Cleveland. The patient had self-administered lyophilized antihemophilic factor every 2 to 4 weeks for the preceding 4 years. He had bilateral, palpable, non-tender, freely movable, cervical, occipital nodes and left axillary nodes,
RATNOFF OD, LEDERMAN MM, JENKINS J. Lymphadenopathy in a Hemophiliac Patient and His Sexual Partner. Ann Intern Med. 1984;100:915. doi: 10.7326/0003-4819-100-6-915_3
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Published: Ann Intern Med. 1984;100(6):915.
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