ROBERT P. KIMBERLY, M.D.; JAMES B. BUSSEL, M.D.; MARGARET W. HILGARTNER, M.D.
To the editor: To explain immunologic abnormalities resembling the acquired immunodeficiency syndrome in patients receiving several blood transfusions and factor VIII concentrates, Gascon and associates (1) suggest that either chronic antigenic stimulation of lymphocytes or exposure to viruses with secondary T-cell activation may play a role. In patients with hemophilia, we have gathered data that show that factor VIII concentrates modulate both circulating immune complexes and Fc-related mononuclear phagocyte function (2). Each of these effects could potentially contribute to the observed immunologic abnormalities of altered T4/T8 lymphocyte ratios and decreased natural killer cell activity.
After infusions of antihemophilic factor in
KIMBERLY RP, BUSSEL JB, HILGARTNER MW. Hemophilia, Antineoplastic Factor, and Immune Complexes. Ann Intern Med. ;100:915–916. doi: 10.7326/0003-4819-100-6-915_4
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Published: Ann Intern Med. 1984;100(6):915-916.
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