CLAUDE K. LARDINOIS, M.D.; ERNEST L. MAZZAFERRI, M.D.; D. BYRON MCGREGOR, M.D.
To the editor: Aldosterone-producing adenoma and hyperplasia are found in most patients with primary aldosteronism. The distinction between the two is important because surgery is likely to cure the hypertension with an aldosterone-producing adenoma but is seldom helpful in hyperplasia. An early morning postural fall in plasma aldosterone—actually the result of diurnal adrenocorticotrophin variation—suggests an aldosterone-producing adenoma, whereas the opposite usually occurs with hyperplasia. We report the case of a patient who was incorrectly thought to have hyperplasia because of a postural rise in plasma aldosterone.
A 54-year-old man presented with blood pressure of 200/120 mm Hg and a serum
LARDINOIS CK, MAZZAFERRI EL, MCGREGOR DB. Plasma Cortisol and Primary Aldosteronism. Ann Intern Med. 1984;100:917–918. doi: 10.7326/0003-4819-100-6-917
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Published: Ann Intern Med. 1984;100(6):917-918.
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