B. ROBERT MEYER, M.D.; MARGARET LEWIN, M.D.; MARK PASMANTIER, M.D.; DENNIS E. DRAYER, M.D.; MARCUS M. REIDENBERG, M.D.
To the editor: Benzodiazepines have been reported to be useful in the control of chemotherapy-induced emesis (1-3). Metoclopramide at doses of 2 mg/kg body weight every 2 hours is the single best agent for the control of cisplatin-induced emesis (4). We did a clinical trial to assess the usefulness of adding diazepam to a standard metoclopramide regimen for the control of cisplatin-induced emesis.
Eligible patients were receiving cisplatin at doses of 60 to 100 mg/m2 body surface area as part of a combination chemotherapy regimen and had no contraindication to either metoclopramide or diazepam. Metoclopramide dosage was 2 mg/kg every
MEYER BR, LEWIN M, PASMANTIER M, DRAYER DE, REIDENBERG MM. Metoclopramide and Chemotherapy-Induced Emesis. Ann Intern Med. ;101:141–142. doi: 10.7326/0003-4819-101-1-141
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Published: Ann Intern Med. 1984;101(1):141-142.
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