MICHAEL N. DUDLEY, PHARM, D.; RICHARD QUINTILIANI, M.D.; CHARLES H. NIGHTINGALE, PH.D.; NANCY GONTARZ, B.S.
To the editor: A report describing systemic absorption of vancomycin after oral administration in a patient with renal failure and Clostridium difficile-induced pseudomembranous colitis appeared in the April issue (1). We recently assayed single serum samples collected from 12 patients with varying degrees of renal function who were receiving oral vancomycin, 500 mg four times daily, for toxin-proven, C. difficile-induced, antibiotic-associated diarrhea and colitis. Samples were collected early in the course (within the first 4 days of therapy), before attaining a clinical response, to assess the effect of active C. difficile-induced diarrhea or colitis on vancomycin absorption.
Serum vancomycin concentrations
DUDLEY MN, QUINTILIANI R, NIGHTINGALE CH, GONTARZ N. Absorption of Vancomycin. Ann Intern Med. ;101:144. doi: 10.7326/0003-4819-101-1-144_1
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Published: Ann Intern Med. 1984;101(1):144.
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