HENRY M. FARIS JR., M.D.; DAVID W. POTTS, M.D.
To the editor: Pharmacologic data on moxalactam levels in pleural fluids are limited. We had an opportunity to evaluate levels in noninfected hospitalized patients.
Six seriously ill patients (two with congestive heart failure; three with metastatic carcinoma; and one with idiopathic pleural effusion), ages 59 to 84 years, were given moxalactam, 1 g over 20 minutes by intravenous infusion. Pleural fluids were aspirated at 1 or 2 hours after infusion (or both) by thoracentesis in four patients and by chest-tube drainage in two patients.
Nine samples each of pleural fluid and serum were collected at 1 hour. Pleural levels of
FARIS HM, POTTS DW. Moxalactam in Pleural Fluids. Ann Intern Med. ;101:144. doi: 10.7326/0003-4819-101-1-144_2
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Published: Ann Intern Med. 1984;101(1):144.
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