DONALD J. KENNEDY, M.D.; RICHARD N. GREENBERG, M.D.; LESLIE W. MILLER, M.D.
To the editor: Kaplan and associates described their experience with continuous hemofiltration in the March issue (1, 2). Although this technique appears to be extremely useful for the removal of water, salt, and other unwanted low-molecular-weight substances, we are concerned about the lack of information on drug clearance by this technique. Our limited clinical experience with slow continuous ultrafiltration has shown that selected aminoglycoside antimicrobials with low-protein-binding characteristics and a low toxic to therapeutic concentration ratio are significantly cleared by this procedure. Although ultrafiltration without fluid replacement theoretically should not alter the net metabolism of drug in these patients, the
KENNEDY DJ, GREENBERG RN, MILLER LW. Continuous Hemofiltration. Ann Intern Med. ;101:145–147. doi: 10.7326/0003-4819-101-1-145_2
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Published: Ann Intern Med. 1984;101(1):145-147.
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