MARTIN J. CLINE, M.D.; DENNIS J. SLAMON, M.D., Ph.D.; JOSEPH S. LIPSICK, M.D., Ph.D.
Cellular oncogenes comprise a small family of genes, highly conserved throughout vertebrate evolution, that code for proteins with diverse functions including DNA binding, protein kinase, and cellular growth factor activities. Cellular oncogenes are important in certain aspects of the proliferation and differentiation of normal cells. Under some circumstances these genes may also induce malignant transformation of normal cells. Various mechanisms may underlie their involvement in carcinogenesis. Incorporation of all, or part of, cellular oncogenes into RNA tumor viruses, mutations in gene structure, or translocation of cellular oncogenes from one chromosome to another may all be associated with the induction of malignant change in cells. In some of these situations altered oncogene products are made. Knowledge about the biology of oncogenes may lead to improved techniques for cancer detection and perhaps new approaches to cancer treatment.
MARTIN J. CLINE, DENNIS J. SLAMON, JOSEPH S. LIPSICK. Oncogenes: Implications for the Diagnosis and Treatment of Cancer. Ann Intern Med. 1984;101:223–233. doi: 10.7326/0003-4819-101-2-223
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Published: Ann Intern Med. 1984;101(2):223-233.
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