RICHARD F. LEIGHTON, M.D.; THEODORE D. FRAKER JR., M.D.
In this issue Rozanski and colleagues (1) discuss a problem common to all studies that attempt to establish sensitivity and specificity of medical tests: the definition of normal in the comparison group. The specificity of one test that has frequently been used to detect coronary artery disease, exercise radioangiography, is contrasted in three "normal" groups: patients with normal coronary arteries as shown by angiography, uncatheterized patients who have a calculated low probability of having coronary artery disease, and normal volunteers. An abnormal response in left ventricular ejection fraction with exercise (defined as less than a 0.05 increase) was found in
LEIGHTON RF, FRAKER TD. Who Is Normal?. Ann Intern Med. ;101:254–255. doi: 10.7326/0003-4819-101-2-254
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Published: Ann Intern Med. 1984;101(2):254-255.
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