E. TABOR, M.D.; R.J. GERETY, M.D.; P.G. FOUTCH, D.O.; W.D. CAREY, M.D.
To the editor: In a recent letter Leibowitz and Vladutiu (1) question whether increased sensitivity of radioimmunoassays for antibody to the hepatitis B surface antigen (anti-HBs) has resulted in the detection of low titers of cross-reacting antibodies that are not specific for the hepatitis B surface antigen (HBsAg). This possibility has led some authors to recommend that low anti-HBs titers (low radioimmunoassay ratios) not be considered indicative of a protective level of anti-HBs, when deciding who should receive the hepatitis B vaccine among persons at high risk for hepatitis B infection (2).
In contrast, the anti-HBs detected in the serum
TABOR E, GERETY R, FOUTCH P, CAREY W. Specificity of Tests for Antibody to Hepatitis B Surface Antigen in Patients with Concomitant Antibody and Antigen. Ann Intern Med. ;101:277. doi: 10.7326/0003-4819-101-2-277_1
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Published: Ann Intern Med. 1984;101(2):277.
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