ELLEN K. MITCHELL, M.D.
To the editor: It has recently come to our attention that flucytosine can produce a falsely elevated serum creatinine.
A 63-year-old white man had been treated with steroids for a blood dyscrasia. He presented in January 1984 with a 1-month history of headache, fever, eye pain, confusion and dysarthria. He was diagnosed as having cryptococcal meningitis and was treated with amphotericin B (0.4 mg/kg body weight •d) and flucytosine (125 mg/kg body weight •d). During his treatment blood samples for serum creatinine were run simultaneously on both the ACA (Dupont Instruments, Wilmington, Delaware) and EKTACHEM (Eastman Kodak Co., Rochester, New
MITCHELL EK. Flucytosine and False Elevation of Serum Creatinine Level. Ann Intern Med. ;101:278. doi: 10.7326/0003-4819-101-2-278_1
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Published: Ann Intern Med. 1984;101(2):278.
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