JOSEPH GUTMAN, M.D.; ROBERT A. ADLER, M.D.
To the editor: Marcus and colleagues in their recent article (1) show that 10 of 14 postmenopausal women with hyperparathyroidism, when treated with conjugated estrogens, had a significant improvement in their serum calcium, 24-hour urinary calcium, alkaline phosphatase, and urinary hydroxyproline concentrations and bone histologic features. They postulate that the primary effect of estrogens is to "reduce the impact of PTH [parathyroid hormone] on bone." Nevertheless, they fail to mention that estrogens in the doses used in their study, can substantially increase the serum levels of calcitonin (2-4); this hormone may be responsible for some of their results. We believe
GUTMAN J, ADLER RA. Estrogens and Calcitonin in Postmenopausal Women with Hyperparathyroidism. Ann Intern Med. ;101:283. doi: 10.7326/0003-4819-101-2-283_3
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Published: Ann Intern Med. 1984;101(2):283.
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