ERSKINE L. PALMER, Ph.D.; ROSEMARY B. RAMSEY, M.S.; PAUL F. FEORINO, Ph.D.; ALYNE K. HARRISON, B.S.; CIRILO CABRADILLA, Ph.D.; DONALD P. FRANCIS, M.D., D.Sc.; MAN-CHIU POON, M.D.; BRUCE L. EVATT, M.D.
Fresh and cultured peripheral blood cells from two patients with hemophilia A and the acquired immunodeficiency syndrome were examined for markers of infection with human T-cell leukemia virus (HTLV) type I. Neither patient had antibody to membrane antigens of HTLV-infected cells at the time of culture. Electron microscopy of peripheral blood cells from Patient 1 and cultured cells from Patient 2 showed type C retrovirus-like particles. Examination of peripheral blood lymphocytes showed other smaller virus-like particles in circulating mononuclear cells from both patients. Indirect immunofluorescence of peripheral mononuclear cells from both patients and of cultured cells from Patient 2 showed staining with antibodies to purified HTLV and to HTLV core proteins p24 and p19.
PALMER EL, RAMSEY RB, FEORINO PF, HARRISON AK, CABRADILLA C, FRANCIS DP, et al. Human T-Cell Leukemia Virus in Lymphocytes of Two Hemophiliacs with the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;101:293–297. doi: 10.7326/0003-4819-101-3-293
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Published: Ann Intern Med. 1984;101(3):293-297.
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