JAMES J. TORREY, M.D.; SURESH B. KATAKKAR, M.D.
CENTRAL NERVOUS SYSTEM infiltration in Waldenstrom's macroglobulinemia is uncommon and difficult to diagnose in living patients. We report the case of a patient in whom we were able to detect meningeal involvement by biopsy and subsequently successfully treat the condition.
In 1977, a 69-year-old woman with progressive weakness was found to have blood and bone marrow features of Waldenstrom's macroglobulinemia. She was treated with various regimens, including chlorambucil, cyclophosphamide, vincristine, bleomycin, and prednisone, over a 6-year period, with responses of 4 months to 2 years. Her serum IgM (kappa) level had decreased from 7360 IU (normal range, 69 to 322
TORREY JJ, KATAKKAR SB. Treatable Meningeal Involvement in Waldenstrom's Macroglobulinemia. Ann Intern Med. ;101:345–347. doi: 10.7326/0003-4819-101-3-345
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Published: Ann Intern Med. 1984;101(3):345-347.
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