C.S. TSAO, PH.D
To the editor: Recently, Swartz and associates (1) have reported the case of a patient with hyperoxaluria and renal insufficiency related to ascorbic acid administration during total parenteral nutrition.
During the last 11 years, we have been receiving increasing numbers of questions on the effect of large intake of ascorbic acid on the excretion of oxalic acid. Some reports in the literature have suggested that daily ingestion of gram quantities slightly or severely increased oxalic acid excretion in healthy persons and also in patients with urolithiasis. Other reports have stated that urinary oxalate excretion of healthy persons or those with
TSAO C. Ascorbic Acid Administration and Urinary Oxalate. Ann Intern Med. 1984;101:405–406. doi: 10.7326/0003-4819-101-3-405_2
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Published: Ann Intern Med. 1984;101(3):405-406.
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