CHARLOTTE CUNNINGHAM-RUNDLES, M.D., Ph.D.; FREDERICK P. SIEGAL, M.D.; ELIZABETH M. SMITHWICK, M.D.; ALISE LION-BOULÉ, R.N.; SUSANNA CUNNINGHAM-RUNDLES, Ph.D.; JOSEPH O'MALLEY, M.D.; SILVIO BARANDUN, M.D.; ROBERT A. GOOD, M.D., Ph.D.
Twenty-one patients with primary humoral immunodeficiency were treated for 1 year with a chemically intact immunoglobulin, 300 mg/kg body weight given intravenously every 3 weeks, to compare immunoglobulin levels and clinical status with results achieved after standard treatment with intramuscular immunoglobulin given previously for 1 year. A substantial reduction of specific acute illnesses and antibiotic use was found for 18 of the 21 patients, particularly during the second 6 months of treatment. Average IgG levels before intravenous infusion were increased 243 mg/dL over previous intramuscular pre-injection levels. Adverse effects were recorded for 2.5% of infusions.
CUNNINGHAM-RUNDLES C, SIEGAL FP, SMITHWICK EM, LION-BOULÉ A, CUNNINGHAM-RUNDLES S, O'MALLEY J, et al. Efficacy of Intravenous Immunoglobulin in Primary Humoral Immunodeficiency Disease. Ann Intern Med. ;101:435–439. doi: 10.7326/0003-4819-101-4-435
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Published: Ann Intern Med. 1984;101(4):435-439.
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