LOUIS ISOLA, M.D.; ALICE FORSTER, R.N.; LOUIS M ALEDORT, M.D.
To the editor: Desamino-D-arginine vasopressin has been reported to be a useful prophylactic as well as therapeutic agent in the management of patients with mild hemophilia, von Willebrand's disease, and uremic bleeding disorders (1, 2). Until recently, replacement therapy was the only treatment available for this group of patients. This treatment is associated with the risk of transmission of various viral diseases, inhibitors, immune complexes, and more recently, the acquired immunodeficiency syndrome.
The mechanisms that alter bleeding time and raise factor VIII as well as von Willebrand factors after desamino-D-arginine vasopressin are not fully understood. The changes in hemostatic components
ISOLA L, FORSTER A, ALEDORT LM. Desamino-D-Arginine Vasopressin and Bleeding Time in von Willebrand's Disease. Ann Intern Med. ;101:719–720. doi: 10.7326/0003-4819-101-5-719_3
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Published: Ann Intern Med. 1984;101(5):719-720.
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