HARVEY J. ALTER, M.D.; PAUL V. HOLLAND, M.D.
Elsewhere in this issue, Stevens and associates (1) have detailed the second major finding of the Transfusion-Transmitted Viruses (TTV) Study, showing a significant correlation between the presence of antibody to the hepatitis B core antigen (anti-HBc) in donors, and the occurrence of non-A, non-B hepatitis in recipients of their blood. Previously, the TTV study had shown a similar correlation between donor alanine aminotransferase (ALT) and recipient hepatitis (2).
The TTV study was a superbly conducted, controlled, prospective study of transfusion-associated hepatitis. The criteria for assessing hepatitis were valid and patient follow-up was excellent. As a result, the data
ALTER HJ, HOLLAND PV. Indirect Tests to Detect the Non-A, Non-B Hepatitis Carrier State. Ann Intern Med. ;101:859–861. doi: 10.7326/0003-4819-101-6-859
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Published: Ann Intern Med. 1984;101(6):859-861.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease.
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