DENIS WAKEFIELD, M.B.B.S.
To the editor: Recurrent genital infection with herpes simplex virus is a common clinical problem associated with considerable morbidity. A large number of different therapeutic regimes have previously been reported. The use of immunomodulatory agents, such as Cimetidine, has not been comprehensively assessed; however, experience with this agent in the treatment of other herpes viral infections indicates a possible beneficial effect (1, 2). The mode of action of Cimetidine in this context has not been fully elucidated but may relate to the effect of the drug on suppressor T-cell function (3).
Over a 6-month period, six patients (three men and
WAKEFIELD D. Cimetidine in Recurrent Genital Herpes Simplex Infection. Ann Intern Med. 1984;101:882. doi: 10.7326/0003-4819-101-6-882_2
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Published: Ann Intern Med. 1984;101(6):882.
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