JAMES D. DICK, Ph.D.; BRUCE R. ROSENGARD, B.S.; WILLIAM G. MERZ, Ph.D.; ROBERT K. STUART, M.D.; GROVER M. HUTCHINS, M.D.; REIN SARAL, M.D.
Disseminated candidiasis is a significant cause of morbidity and mortality in immunocompromised patients. Candida albicans is the commonest pathogen associated with systemic candidiasis, although other species do cause infections (1). Amphotericin B is the drug of choice for treatment of disseminated candidal infection, and the development of amphotericin B resistance is considered rare. We report the case of a patient with aplastic anemia who died from disseminated infection caused by a strain of C. guilliermondii that developed progressive resistance to amphotericin B.
A 52-year-old white woman was admitted to The Johns Hopkins Oncology Center for evaluation and treatment of aplastic
DICK JD, ROSENGARD BR, MERZ WG, STUART RK, HUTCHINS GM, SARAL R. Fatal Disseminated Candidiasis Due to Amphotericin-B-Resistant Candida guilliermondii. Ann Intern Med. ;102:67–68. doi: 10.7326/0003-4819-102-1-67
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Published: Ann Intern Med. 1985;102(1):67-68.
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