AARON KNECHT, M.D.; FREDERICK C. de BEER, M.D.; MORDECHAI PRAS, M.D.
Amyloid a protein is the subunit of amyloid fibrils that occurs in the forms of amyloidosis commonest in humans and ubiquitous in animals (1, 2). Its unique nature prompted a search for its substrate in normal serum and led to the discovery, by immunologic techniques, of serum amyloid A protein (3, 4), a high-density apolipoprotein that behaves like an acute-phase reactant and has an aminoterminal identical with that of amyloid A protein.
The first complete amino acid sequence of amyloid A protein came from a sample of amyloid from a patient with familial Mediterranean fever. A rise in serum levels
KNECHT A, de BEER FC, PRAS M. Serum Amyloid A Protein in Familial Mediterranean Fever. Ann Intern Med. ;102:71–72. doi: 10.7326/0003-4819-102-1-71
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Published: Ann Intern Med. 1985;102(1):71-72.
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