JAMES L. LEVENSON, M.D.; KRISTINE KENNEDY, M.D.
To the editor: Nifedipine is a calcium channel blocker widely used in the treatment of angina. Its adverse effects include flushing, dizziness, headache, pedal edema, upper gastrointestinal distress, weakness, paresthesias, and transient hypotension. Uncommon serious adverse effects may include congestive heart failure, increased angina, and cerebral ischemia (1). We have recently encountered distortion of taste (dysgeusia) and smell (dysosmia) in two patients taking nifedipine.
A 71-year-old woman was hospitalized with unstable angina. She had been receiving nifedipine, 30 to 80 mg/d for 13 months, in addition to nitrates, digoxin, and furosemide. She also had a profound unexplained weight loss (27
LEVENSON JL, KENNEDY K. Dysomia, Dysgeusia, and Nifedipine. Ann Intern Med. ;102:135–136. doi: 10.7326/0003-4819-102-1-135_2
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Published: Ann Intern Med. 1985;102(1):135-136.
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