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A detailed, clinically oriented monograph. Opens with a concise perspective on the varieties of toxicities and then reviews briefly the pharmacology of antineoplastic drugs and the principles of mechanisms of action. Thirteen central chapters detail specific types of toxicities: hypersensitivity reactions; skin effects; oral lesions; toxicities affecting the heart, lungs, kidneys, gut (including liver), gonadal functions and sexuality, nerve and brain, blood and marrow, vessels, endocrine functions; and potential for teratogenecity. Chapters follow on the timing of chemotherapy in relation to potential for toxicity; problems of second malignancies associated with chemotherapy; and survival into adult life after a childhood malignancy.
Toxicity of Chemotherapy.. Ann Intern Med. ;102:152. doi: 10.7326/0003-4819-102-1-152_4
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© 2018
Published: Ann Intern Med. 1985;102(1):152.
DOI: 10.7326/0003-4819-102-1-152_4