MARCOS A. SOUZA LIMA, M.D.
To the editor: In the report by Bredfeldt and von Huene on another possible case of ranitidine hepatitis (1) two cited studies are misinterpreted. First, my previous report of ranitidine hepatitis describes a definite case based on positive dechallenge, liver biopsy findings, and rechallenge (2, 3), not a possible case as they state. Most cases so far reported have lacked a drug rechallenge. Understandably, a rechallenge may, at times, raise ethical questions, but it is essential in verifying the relation between drug and adverse event. Furthermore, a rechallenge may provide insight into the pathogenesis. For certain drug reactions, laboratory techniques
SOUZA LIMA MA. Ranitidine and the Liver. Ann Intern Med. ;102:273–274. doi: 10.7326/0003-4819-102-2-273
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Published: Ann Intern Med. 1985;102(2):273-274.
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