RICHARD B. MAZESS, Ph.D.
To the editor: Meier and associates (1) showed, using single-energy computed tomography, that the apparent aging loss of vertebral bone in men was much greater than the decrease in compact bone (12% as compared with 3% per decade). In fact this large vertebral loss was comparable to the computed tomographic changes seen in the spine of women. However, the aging change in chemically determined density of trabecular bone averages about 7% per decade in both sexes (2). One explanation for this high apparent rate of loss in both men and women is the influence of increased marrow fat. Laval-Jeantet and
MAZESS RB. Marrow Fat and Estimates of Bone Loss. Ann Intern Med. ;102:276–277. doi: 10.7326/0003-4819-102-2-276
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Published: Ann Intern Med. 1985;102(2):276-277.
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