JEROME E. GROOPMAN, M.D.; KENNETH H. MAYER, M.D.; M. G. SARNGADHARAN, Ph.D.; DAVID AYOTTE, M.P.H.; ANTHONY L. DEVICO, B.S.; ROBERT FINBERG, M.D.; ANN H. SLISKI, D.Sc.; J. DAVIS ALLAN, M.D.; ROBERT C. GALLO, M.D.
We studied a cohort of 45 homosexual men with the acquired immunodeficiency syndrome, 78 with persistent unexplained generalized lymphadenopathy, and 160 asymptomatic homosexual controls for serologic evidence of infection with human T-lymphotropic virus type III (HTLV-III). Study participants were recruited from a community-based health center and a university hospital practice. Ninety-eight percent of men with the syndrome and greater than 90% of men with generalized lymphadenopathy had antibody to HTLV-III, while 21% of the controls were positive (p 〈 0.001). Six patients with generalized lymphadenopathy developed the acquired immunodeficiency syndrome over 2 years; all were seropositive for HTLV-III. Thirty-six asymptomatic controls had had sexual contact with a man with the syndrome; receptive anal intercourse in this group was associated with seropositivity for HTLV-III. These data suggest that persistent generalized lymphadenopathy and the acquired immunodeficiency syndrome are part of a clinical spectrum of HTLV-III infection and that most high-risk homosexual men in some regions of the United States have not yet been infected with this virus.
GROOPMAN JE, MAYER KH, SARNGADHARAN MG, AYOTTE D, DEVICO AL, FINBERG R, et al. Seroepidemiology of Human T-Lymphotropic Virus Type III Among Homosexual Men with the Acquired Immunodeficiency Syndrome or Generalized Lymphadenopathy and Among Asymptomatic Controls in Boston. Ann Intern Med. 1985;102:334–337. doi: 10.7326/0003-4819-102-3-334
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Published: Ann Intern Med. 1985;102(3):334-337.
HIV, Infectious Disease.
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