RAMON DUARTE, M.D.
To the editor: In the excellent review of cyclosporine recently published in this journal (1), the section on nephrotoxic side effects offered no adequate explanation for the frequent reduction in glomerular filtration rate, hypertension, or hyperkalemia that accompany the use of this drug. Of interest in this regard is one study (2) in which patients treated with cyclosporine showed evidence of increased systemic and renal vascular resistance, decreased renal plasma (and blood) flow, and reduced plasma renin activity associated with hypertension, as compared to patients given azathioprine.
Could those physiologic (and morphologic) derangements induced by cyclosporine be the result of
DUARTE R. Cyclosporine: Renal Effects and Prostacyclin. Ann Intern Med. ;102:420. doi: 10.7326/0003-4819-102-3-420_1
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Published: Ann Intern Med. 1985;102(3):420.
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