DANIEL V. EHRENSAFT, M.D.; MICHAEL M. SAFANI, Pharm.D.
To the editor: Intravenous acyclovir has been shown to be effective in the treatment of initial and recurrent herpes simplex virus infections in immunocompetent and immunocompromised persons (1, 2). Although the in-vitro data are impressive, limited information is available on its efficacy in the treatment of varicella zoster encephalitis (3). We report a case of culture-proven disseminated varicella zoster infection and encephalitis successfully treated with high-dose intravenous acyclovir.
A 37-year-old white woman with acute lymphoblastic leukemia and leukemic meningitis currently in remission had previously received whole-brain irradiation (total dose, 4400 rad) and then intermittent maintenance chemotherapy with prednisone, vincristine, thioguanine,
EHRENSAFT DV, SAFANI MM. Acyclovir and Disseminated Varicella Zoster and Encephalitis. Ann Intern Med. ;102:421. doi: 10.7326/0003-4819-102-3-421_1
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Published: Ann Intern Med. 1985;102(3):421.
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