DANIEL V. EHRENSAFT, M.D.; MICHAEL M. SAFANI, Pharm.D.
To the editor: Intravenous acyclovir has been shown to be effective in the treatment of initial and recurrent herpes simplex virus infections in immunocompetent and immunocompromised persons (1, 2). Although the in-vitro data are impressive, limited information is available on its efficacy in the treatment of varicella zoster encephalitis (3). We report a case of culture-proven disseminated varicella zoster infection and encephalitis successfully treated with high-dose intravenous acyclovir.
A 37-year-old white woman with acute lymphoblastic leukemia and leukemic meningitis currently in remission had previously received whole-brain irradiation (total dose, 4400 rad) and then intermittent maintenance chemotherapy with prednisone, vincristine, thioguanine,
DANIEL V. EHRENSAFT, MICHAEL M. SAFANI. Acyclovir and Disseminated Varicella Zoster and Encephalitis. Ann Intern Med. 1985;102:421. doi: 10.7326/0003-4819-102-3-421_1
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Published: Ann Intern Med. 1985;102(3):421.
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