NORMAN M. KAPLAN, M.D.
To the editor: A massive campaign, including eight-page, heavy-paper advertisements in most medical journals, has been mounted for a new formulation of triamterene and hydrochlorothiazide, Maxzide (Lederle Laboratories, Wayne, New Jersey). The manufacturers have emphasized the improved, virtually 100% bioavailability of both ingredients in their formulation compared with that of the only other available formulation, Dyazide (SmithKline & French Co., Carolina, Puerto Rico). Dyazide has become the single largest-used diuretic product in the United States and in fact is the number one prescribed drug in volume, with 1983 sales of over $210 million.
Dyazide has 25 mg of hydrochlorothiazide, of
KAPLAN NM. Maxzide or Dyazide: A Cautionary Note. Ann Intern Med. ;102:717. doi: 10.7326/0003-4819-102-5-717_1
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Published: Ann Intern Med. 1985;102(5):717.
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