HAROLD A. KESSLER, M.D.; ALAN A. HARRIS, M.D.; JOHN A. PAYNE, M.D.; EDSEL HUDSON, M.D.; BENJAMIN POTKIN, M.D.; STUART LEVIN, M.D.
The epidemiologic and serologic differences between hospital employees with antibodies to hepatitis B surface antigen (anti-HBs) alone or in combination with antibodies to hepatitis B core antigen (anti-HBc) were evaluated. Of 105 employees with anti-HBs, 38 (36%) did not have anti-HBc. Sera from employees with anti-HBs alone had significantly lower mean sample ratio units of anti-HBs than sera with both antibodies (15.9 ± 43.2 as compared to 110.3 ± 73.9, p < 0.0005) and more commonly had less than 10 sample ratio units of anti-HBs (32 [84%] of 38 as compared to 9 [13%] of 67, p = 0.0001). The anti-HBs in sera with anti-HBs alone was predominantly IgM as shown by inactivation with 2-mercaptoethanol and the presence of anti-HBs activity in serum IgM fractions. Failure of protection from hepatitis B virus infection in persons with anti-HBs alone and the presence of nonprotective IgM anti-HBs in chimpanzees has been reported. Our data suggest the use of anti-HBs as a single serologic screening test for hepatitis B virus immunization programs may not be reliable in identifying employees with protective antibodies.
HAROLD A. KESSLER, ALAN A. HARRIS, JOHN A. PAYNE, EDSEL HUDSON, BENJAMIN POTKIN, STUART LEVIN. Antibodies to Hepatitis B Surface Antigen as the Sole Hepatitis B Marker in Hospital Personnel. Ann Intern Med. 1985;103:21–26. doi: 10.7326/0003-4819-103-1-21
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Published: Ann Intern Med. 1985;103(1):21-26.
Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Prevention/Screening.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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