JOHN P. MULROW, M.D.; CYNTHIA D. MULROW, M.D., M.Sc.; WILLIAM J. McKENNA, M.D.
Amiodarone is an effective antiarrhythmic agent (1-5) but its use is often limited by unwanted effects (6). Photosensitivity develops in as many as 75% of white patients and is severe in more than 30% (7). No known clinical features identify susceptible patients, and recommended therapies such as sunscreens have not proved effective.
Pyridoxine was recently reported to suppress amiodarone-induced photosensitivity in three patients (8), but in-vitro studies (9) suggest pyridoxine enhances rather than suppresses amiodarone phototoxicity. Potential adverse effects indicate the need for thorough evaluation. We did a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of pyridoxine in preventing
MULROW JP, MULROW CD, McKENNA WJ. Pyridoxine and Amiodarone-Induced Photosensitivity. Ann Intern Med. 1985;103:68–69. doi: 10.7326/0003-4819-103-1-68
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Published: Ann Intern Med. 1985;103(1):68-69.
Cardiology, Rhythm Disorders and Devices.
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