CHARLES V. SANDERS, M.D.; RICHARD N. GREENBERG, M.D.; ROBERT L. MARIER, M.D.
Cefamandole and cefoxitin, introduced only 7 years ago, are now the most commonly prescribed parenteral antibiotics in the United States. These drugs are similar to the first-generation cephalosporins in toxicity, but their in-vitro spectrum of activity is greater. Their serum half-lives are longer than those of cephalothin and cephapirin but shorter than that of cefazolin. Although cefamandole has been recommended in empiric therapy for patients with community-acquired pneumonia and as a prophylactic agent for patients having various surgical procedures, other regimens are less expensive and just as effective. Cefamandole should not be used to treat intra-abdominal, enterobacter, or ampicillin-resistant Haemophilus influenzae infections. Cefoxitin is effective in the treatment and prevention of mixed aerobic-anaerobic skin and soft-tissue, intra-abdominal, gynecologic, and penicillinase-producing, spectinomycin-resistant Neisseria gonorrhoeae infections. Cefoxitin represents a greater advance than cefamandole in our continuing search for safe and more effective antimicrobial agents.
CHARLES V. SANDERS, RICHARD N. GREENBERG, ROBERT L. MARIER. Cefamandole and Cefoxitin. Ann Intern Med. 1985;103:70–78. doi: 10.7326/0003-4819-103-1-70
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Published: Ann Intern Med. 1985;103(1):70-78.
Emergency Medicine, Infectious Disease, Pneumonia, Pulmonary/Critical Care, Sexually Transmitted Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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