CHIKASHI KITOH, M.D.
To the editor: The clinical observation by Breslau and colleagues (1) appears to be significant in suggesting a new mechanism for lymphoma-associated hypercalcemia. However, I have some questions about their conclusion.
I have no clinical data with which to conclude that their three patients with lymphoma each have an unrelated elevation in serum calcitriol concentrations. I wonder whether the hypercalcemia can be explained only by the high levels of serum calcitriol. Even now, there is controversy on the specific mechanisms responsible for cancer-associated hypercalcemia (2). The relation between concentrations of serum calcium and calcitriol levels does not mean that the
KITOH C. Lymphoma, Hypercalcemia, and Serum Calcitriol Levels. Ann Intern Med. ;103:152–153. doi: 10.7326/0003-4819-103-1-152
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Published: Ann Intern Med. 1985;103(1):152-153.
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