ERNEST BRIËT, M. D.; MERK C. WIJNANDS, M.D.; JAN J. VELTKAMP, M.D.
Hemophilia B Leyden is an X-linked recessively inherited bleeding disorder that cannot be distinguished from severe cross-reactive material-negative hemophilia B in patients under 15 years of age. After puberty, however, the hemorrhagic symptoms diminish and the factor IX levels begin to rise (1, 2). Until now, the cases of two unrelated families with this disease have been reported: one in the Netherlands (1, 2) and one in Greece (Mandalaki T, Louizou C, Dimitriadou C. Haemophilia B Leyden in Greece. Presented at the 13th Congress of the World Federation of Hemophilia, Tel Aviv, Israel, 8-13 July 1979). The close association of
BRIËT E, WIJNANDS MC, VELTKAMP JJ. The Prophylactic Treatment of Hemophilia B Leyden with Anabolic Steroids. Ann Intern Med. ;103:225–226. doi: 10.7326/0003-4819-103-2-225
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Published: Ann Intern Med. 1985;103(2):225-226.
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