D. ADU, M.D.; C. J. LOTE, Ph.D.; J. MICHAEL, F.R.C.P.; J. H. TURNEY, M.R.C.P.; P. MCMASTER, F.R.C.S.
To the editor: Cyclosporine and its nephrotoxicity have recently been reviewed in your journal (1). Subsequently, Dr. Duarte (2) asked whether the nephrotoxicity of cyclosporine might result from an effect on prostaglandin metabolism.
We have recently suggested that the nephrotoxicity, hypertension, hyperkalaemia, and haemolytic-uraemic syndrome seen in some patients given cyclosporine therapy could be explained if this drug inhibited renal prostaglandin synthesis (3). We studied urine prostaglandin E2 excretion in female renal allograft recipients treated with either prednisolone and azathioprine (11 patients) or prednisolone and cyclosporine (14 patients). The mean urinary prostaglandin E2 excretion in patients given prednisolone and cyclosporine
ADU D, LOTE CJ, MICHAEL J, TURNEY JH, MCMASTER P. Cyclosporine and Prostaglandins. Ann Intern Med. ;103:303. doi: 10.7326/0003-4819-103-2-303_1
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Published: Ann Intern Med. 1985;103(2):303.
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