J. AUWERX, M.D.; R. BOUILLON, M.D.; M. DEMEDTS, M.D.
To the editor: Law and Heath (1) have compiled an important and extensive review of their experience with familial benign hypercalcemia. We want to comment on two problems in their review.
First, although we agree that the parathyroid glands are not functioning autonomously in patients with familial benign hypercalcemia, we found in patients we examined an elevated "setpoint" of the parathyroid glands to extracellular calcium (2). In response to edetic-acid-induced hypocalcemia, our patients had an increase in the serum parathyroid hormone level that was intermediate between levels for healthy controls and patients with hyperparathyroidism due either to parathyroid hyperplasia or
AUWERX J, BOUILLON R, DEMEDTS M. Familial Benign Hypercalcemia. Ann Intern Med. ;103:304–305. doi: 10.7326/0003-4819-103-2-304_2
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Published: Ann Intern Med. 1985;103(2):304-305.
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