The commonest cause of transmural myocardial infarction is thrombotic occlusion of a coronary artery (1, 2). With improved therapy for life-threatening arrhythmias in the setting of acute myocardial infarction, cardiac pump failure has emerged as the principal in-hospital cause of death in these patients. Efforts to decrease mortality related to pump failure have focused on reducing the extent of myocardial damage by reducing myocardial oxygen demand and improving myocardial oxygen supply. Thrombolytic therapy in the setting of acute myocardial infarction involves the use of pharmacologic agents to lyse coronary thrombi and to reperfuse jeopardized myocardium, thereby improving myocardial oxygen supply.
Thrombolysis for Evolving Myocardial Infarction. Ann Intern Med. ;103:463–469. doi: 10.7326/0003-4819-103-3-463
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Published: Ann Intern Med. 1985;103(3):463-469.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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