HOWARD R. SMITH, M.D.; MICHAEL SELDIN, M.D., Ph.D.; ALFRED D. STEINBERG, M.D.; JOSEF S. SMOLEN, M.D.; WOLFGANG R. MAYR, M.D.; RICHARD J. DAVEY, M.D.; ELAINE S. JAFFE, M.D.
To the editor: Angioimmunoblastic lymphadenopathy is a rare clinicopathologic entity that is characterized by lymphadenopathy, systemic autoimmune features, and a high potential for lymphoid malignancy (1, 2). The systemic features resemble those found in systemic lupus erythematosus and primary sicca syndrome. Because the latter disorders are associated with certain HLA types (3, 4), we investigated a potential relationship between angioimmunoblastic lymphadenopathy and HLA phenotypes. Despite the very rare occurrence of the disease, we have been able to study seven white patients with this diagnosis over the last 3 years. All seven have fulfilled the classical histologic criteria for the disease
SMITH HR, SELDIN M, STEINBERG AD, SMOLEN JS, MAYR WR, DAVEY RJ, et al. HLA Antigens in Angioimmunoblastic Lymphadenopathy. Ann Intern Med. ;103:471. doi: 10.7326/0003-4819-103-3-471_1
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Published: Ann Intern Med. 1985;103(3):471.
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