ROLF A. K. STAHL, M.D.; KANZ LOTHAR, M.D.; SABINE KUDELKA
To the editor: In the March issue Drs. Duarte (1) and Cohen and Strom (2) discussed whether a reduced glomerular filtration rate, hyperkalemia, and vasculopathy noted in patients treated with cyclosporine might be due to an inhibition of renal prostaglandin synthesis. We recently obtained data indicating that cyclosporine treatment reduces renal prostaglandin E2 formation.
We compared the glomerular filtration rate, serum potassium level, and urinary prostaglandin E2 and thromboxane B2 excretion from 11 patients treated with cyclosporine with those in 11 renal transplant recipients who received azathioprine. The daily prednisolone dosage in both groups was not significantly different. No patient received diuretics.
STAHL RAK, LOTHAR K, KUDELKA S. Cyclosporine and Renal Prostaglandin E2 Production. Ann Intern Med. ;103:474. doi: 10.7326/0003-4819-103-3-474_2
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Published: Ann Intern Med. 1985;103(3):474.
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