CHARLES G. HELMICK, M.D.; JEANETTE K. GREEN, M.D.
To the editor: Hypotension is a serious adverse reaction to pentamidine, a drug used to treat Pneumocystis carinii pneumonia, and it has been reported to occur more frequently after intravenous than intramuscular administration (1-4). Thus, intramuscular injection usually is the preferred route of administration. However, a recent report suggests that moderate or severe hypotension occurs more frequently after intramuscular injection (5).
The frequency of hypotension by route of administration was determined retrospectively through chart review for 167 (90%) of 184 patients who received pentamidine between 7 June and 11 October 1984 at 15 New York City hospitals. Because of
HELMICK CG, GREEN JK. Pentamidine-Associated Hypotension and Route of Administration. Ann Intern Med. ;103:480. doi: 10.7326/0003-4819-103-3-480_1
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Published: Ann Intern Med. 1985;103(3):480.
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