D. KELLEHER, M.R.C.P.I.; N. NOONAN, M.B.; D. G. WEIR, MD., F.R.C.P.I.
To the editor: Although chronic inflammatory bowel disease is not classified as a genetically determined disease, numerous reports have stressed an increased incidence in families ranging from 3% to 35% (1). Reports of clustering among nonsiblings, however, are rare (2) and these cases may be chance occurrences. We report the occurrence of ulcerative colitis in a husband and wife who both had a reduced ratio of helper to suppressor T lymphocytes.
Patient 1: A 46-year-old man presented in 1979 with a 3-year history of diarrhea with passage of blood and mucus through
KELLEHER D, NOONAN N, WEIR DG. Ulcerative Colitis and Abnormal Helper: Suppressor Cell Ratios in a Husband and Wife. Ann Intern Med. ;103:635–636. doi: 10.7326/0003-4819-103-4-635_2
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Published: Ann Intern Med. 1985;103(4):635-636.
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